
Foods rich in vitamin K include beef liver, broccoli, Brussels sprouts, cabbage, collard greens, endive, kale, lettuce, mustard greens, parsley, soy beans, spinach, Swiss chard, turnip greens, watercress, and other green leafy vegetables. While there is no need to avoid products that contain vitamin K, you should maintain a consistent level of consumption of these products. For example, increasing vitamin K levels in the body can promote clotting and reduce the effectiveness of warfarin. Therefore, it is important to keep your vitamin supplement and food intake steady throughout treatment. Taking melatonin with these drugs might increase the risk of seizures.Nutrition and diet can affect your treatment with warfarin. Melatonin can stimulate immune function and interfere with immunosuppressive therapy. This medication used to treat obsessive-compulsive disorder can increase melatonin levels, causing unwanted excessive drowsiness. Use melatonin cautiously if you take drugs such as diazepam (Valium, Valtoco, others) and others that are affected by these enzymes. Cytochrome P450 1A2 (CYP1A2) and cytochrome P450 2C19 (CPY2C19) substrates.Use of contraceptive drugs with melatonin might cause an additive sedative effect and increase possible side effects of melatonin. If you take diabetes medications, talk to your doctor before using melatonin. Melatonin use with these medications might cause an additive sedative effect. Central nervous system (CNS) depressants.Melatonin might worsen blood pressure in people taking blood pressure medications. Melatonin might inhibit the effects of anticonvulsants and increase the frequency of seizures particularly in children with neurological disabilities. Combining use of melatonin with them might increase the risk of bleeding.

These types of drugs, herbs and supplements reduce blood clotting.


Research suggests that melatonin might slightly reduce the time it takes to fall asleep, but its effects on sleep quality and total sleep time aren't clear.

Research shows that melatonin reduces the length of time needed to fall asleep and advances the start of sleep in adults and children with this condition. In this disorder, your sleep pattern is delayed two hours or more from a conventional sleep pattern, causing you to go to sleep later and wake up later. Delayed sleep phase (delayed sleep-wake phase sleep disorder).Melatonin can help improve these disorders in adults and children. Circadian rhythm sleep disorders in the blind.Research on melatonin use for specific conditions shows:
